Galerie: Invasome

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LeciPlex, invasomes, and liposomes: A skin penetration study - ScienceDirect gif 753x224

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LeciPlex, invasomes, and liposomes: A skin penetration study - ScienceDirect


We identified several virulence factors that form the bacterial invasome and may contribute to increasing bacterial virulence and pathogenicity including mainly Gifsy-2 prophage, two different type 6 secretion systems (T6SSs) harbored by Salmonella pathogenicity islands; SPI-6 and SPI-19 respectively and virulence genes; ggt and PagN. Although Vi antigen and the virulence plasmid have been reported previously to contribute to the virulence of S. Dublin we did not detect them in all invasive ...

Via: sciencedirect.com
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LeciPlex, invasomes, and liposomes: A skin penetration study - ScienceDirect jpg 753x375

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LeciPlex, invasomes, and liposomes: A skin penetration study - ScienceDirect


The invasome of Salmonella Dublin as revealed by whole genome sequencing Manal Mohammed, Simon Le Hello, Pimlapas Leekitcharoenphon, Rene Hendriksen; Affiliations Manal Mohammed Department of Biomedical Sciences, Faculty of Science and Technology, University of Westminster Simon Le Hello Unité des Bactéries Pathogènes Entériques, Centre National de Référence des Salmonella, WHO ...

Via: sciencedirect.com
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BID-F1 and BID-F2 Domains of Bartonella henselae Formation of Invasome  Structures png 768x1024

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BID-F1 and BID-F2 Domains of Bartonella henselae Formation of Invasome Structures


A systematic approach to the molecular and cellular basis of Bartonella henselae-triggered invasome formation. Gespeichert in: Verfasser / Beitragende: von Matthias Christoph Truttmann. Ort, Verlag, Jahr: Basel : 2011. Beschreibung: 218 Bl. : Ill. Format: Buch (Hochschulschrift) ID: 50397305X Weitere Ausgaben. Standorte & bestellen ; Beschreibung; Ähnliche Einträge; Felder; IDS Basel Bern ...

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Topical application of temoporfin-loaded invasomes for photodynamic therapy  of subcutaneously implanted tumours in mice: A pilot study - ScienceDirect gif 378x229

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Topical application of temoporfin-loaded invasomes for photodynamic therapy of subcutaneously implanted tumours in mice: A pilot study - ScienceDirect


Start studying Bartonella henselae. Learn vocabulary, terms, and more with flashcards, games, and other study tools.

Via: sciencedirect.com
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A translocated protein of Bartonella henselae interferes with endocytic  uptake of individual bacteria and triggers uptake of large bacterial  aggregates via the invasome - Rhomberg - 2009 - Cellular Microbiology -  Wiley Online Library gif 900x916

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A translocated protein of Bartonella henselae interferes with endocytic uptake of individual bacteria and triggers uptake of large bacterial aggregates via the invasome - Rhomberg - 2009 - Cellular Microbiology - Wiley Online Library


Bacterial internalisation via the invasome was consistently observed with several clinical isolates of B. henselae, while a spontaneous mutant obtained from one of these isolates was impaired in invasome-mediated invasion. Instead, this mutant showed increased uptake of bacteria into perinuclear localising phagosomes, suggesting that invasome-formation may interfere with this alternative ...

Via: wiley.com
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Lipoidal soft hybrid biocarriers in pharmacotherapeutics | Pharmaceutical  Patent Analyst gif 500x327

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Lipoidal soft hybrid biocarriers in pharmacotherapeutics | Pharmaceutical Patent Analyst


VirB/D4 T4SS and Beps of B. henselae. Left, the different virulence phenotypes of the VirB/D4 T4SS and the Beps are summarized in a schematic drawing. It becomes apparent that the diverse cellular activities converge toward the establishment, maintenance, and control of an intracellular niche. Right, the formation of an invasome on human endothelial cells infected with B. henselae is shown as ...

Via: future-science.com
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A translocated protein of Bartonella henselae interferes with endocytic  uptake of individual bacteria and triggers uptake of large bacterial  aggregates via the invasome - Rhomberg - 2009 - Cellular Microbiology -  Wiley Online Library gif 650x928

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A translocated protein of Bartonella henselae interferes with endocytic uptake of individual bacteria and triggers uptake of large bacterial aggregates via the invasome - Rhomberg - 2009 - Cellular Microbiology - Wiley Online Library


Interaction of Bartonella henselae with endothelial cells results in bacterial aggregation on the cell surface and the subsequent engulfment and internalisation of the bacterial aggregate by a unique structure, the invasome. J Cell Sci 110 (Pt 18): 2141 - 2154.

Via: wiley.com
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Proposed mechanism of action of invasomes | Download Scientific Diagram png 707x510

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Proposed mechanism of action of invasomes | Download Scientific Diagram


Next, we show that BepF function during invasome formation can be replaced by the over-expression of constitutive-active Rho GTPases Rac1 or Cdc42. Finally we demonstrate that BID-F1 and BID-F2 domains promote the formation of filopodia-like extensions in NIH 3T3 and HeLa cells as well as membrane protrusions in HeLa cells, suggesting a role for BepF in Rac1 and Cdc42 activation during the ...

Via: researchgate.net
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Bartonella henselae engages inside-out and outside-in signaling by integrin  β1 and talin1 during invasome-mediated bacterial uptake | Journal of Cell  Science jpg 992x585

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Bartonella henselae engages inside-out and outside-in signaling by integrin β1 and talin1 during invasome-mediated bacterial uptake | Journal of Cell Science


Type IV secretion system that mediates by its BepB effector proteins (BepA-G) the invasome-mediate uptake of B. henselae into ECs and inhibition of EC apoptosis, essential for intraerythrocytic bacteremia by B. tribocorum and B. birtlesii, required in the colonization of the primary niche and/or in seeding of the bacteria from the primary niche into the bloodstream (Schulein & Dehio, )

Via: biologists.org
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Pilosebaceous targeting by isotretenoin-loaded invasomal gel for the  treatment of eosinophilic pustular folliculitis: optimizati  1403x632

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Pilosebaceous targeting by isotretenoin-loaded invasomal gel for the treatment of eosinophilic pustular folliculitis: optimizati


Definition of Movsesian. Do you know the meaning of movsesian? alternative form of Movsesyan. Word in 9 letters. This definition of the word Movsesian is from the Wiktionary, where you can also find the etimology, other senses, synonyms, antonyms and examples.

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Invasome Particle Size and the Polydispersity Index. | Download Scientific  Diagram png 850x235

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Invasome Particle Size and the Polydispersity Index. | Download Scientific Diagram


Invasomes are novel vesicles incorporating terpenes with enhanced penetration compared to the conventional liposomes. These are soft liposomal vesicles with ve…

Via: researchgate.net
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BID-F1 and BID-F2 Domains of Bartonella henselae Effector Protein BepF  Trigger Together with BepC the Formation of Invasome Structures g003 1260x2599

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BID-F1 and BID-F2 Domains of Bartonella henselae Effector Protein BepF Trigger Together with BepC the Formation of Invasome Structures


Bartonella species are emerging human pathogens responsible for a wide range of clinical manifestations, including Carrion's disease, trench fever, cat-scratch disease, bacillary angiomatosis-peliosis, endocarditis and bacteraemia. During infection of their human or animal reservoir host(s), these arthropod-borne pathogens typically invade and persistently colonize mature erythrocytes.

Via: plos.org
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TEM analysis of invasome-mediated invasion. HUVECs were infected with... |  Download Scientific Diagram png 850x640

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TEM analysis of invasome-mediated invasion. HUVECs were infected with... | Download Scientific Diagram


Fig. 3. Confocal analysis of invasome-mediated invasion. HUVECs wer hours (E-H) or 30 hours (I-L), washed and fixed with formaldehyde. Spe blue channel in C,G,K) or the totality of bacteria (after permeabilisation filamentous actin was stained by FITC-labelled phalloidin (green channe laser scanning microscopy. An overlay of all three channels is represente internalisation (I-L) of a bacterial ...

Via: researchgate.net
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Smart invasome synthesis, characterizations, pharmaceutical applications,  and pharmacokinetic perspective: a review | Future Journal of  Pharmaceutical Sciences | Full Text png 685x391

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Smart invasome synthesis, characterizations, pharmaceutical applications, and pharmacokinetic perspective: a review | Future Journal of Pharmaceutical Sciences | Full Text


Abstract:Invasomes are novel vesicular systems that exhibit improved transdermal penetration compared to conventional liposomes. These vesicles contain phospholipids, ethanol, and terpene in their structures; these components confer suitable transdermal penetration properties to the soft

Via: springeropen.com
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The physical appearance of liposome, invasome and transfersome... |  Download Scientific Diagram jpg 640x640

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The physical appearance of liposome, invasome and transfersome... | Download Scientific Diagram


Bartonella henselae engages inside-out and outside-in signaling by integrin β1 and talin1 during invasome-mediated bacterial uptake. Journal of Cell Science, Nov 2011 . Matthias C. Truttmann, Benjamin Misselwitz, Sonja Huser, Wolf-Dietrich Hardt, David R. Critchley, Christoph Dehio

Via: researchgate.net
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The invasome of Salmonella Dublin as revealed by whole genome sequencing  1600x2263

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The invasome of Salmonella Dublin as revealed by whole genome sequencing


Profile von Personen mit dem Namen Alex Inva anzeigen. Tritt Facebook bei, um dich mit Alex Inva und anderen Personen, die du kennen könntest, zu...

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Formulation and Evaluation results of Invasome preparations | Download  Scientific Diagram png 850x481

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Formulation and Evaluation results of Invasome preparations | Download Scientific Diagram


Structure Short Article The BID Domain of Type IV Secretion Substrates Forms a Conserved Four-Helix Bundle Topped with a Hook Fre´de´ric V. Stanger, 1 ,2 56 Tjaart A.P. de Beer, David M. Dranow,3 4 Tilman Schirmer,2,* Isabelle Phan,3 and Christoph Dehio1 ,7 * 1Focal Area Infection Biology, Biozentrum University of Basel, 4056 Basel, Switzerland 2Focal Area Structural Biology and Biophysics ...

Via: researchgate.net
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Bartonella henselae engages inside-out and outside-in signaling by integrin  β1 and talin1 during invasome-mediated bacterial uptake | Journal of Cell  Science jpg 1188x1280

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Bartonella henselae engages inside-out and outside-in signaling by integrin β1 and talin1 during invasome-mediated bacterial uptake | Journal of Cell Science


Bacterial internalization via the invasome pathway was consistently observed with different isolates of B. henselae. The invasome pathway is probably equivalent to or a variant of macropinocytosis, a process which leads to entrapment of large volumes of fluid or particles, including apoptotic cells, within intracellular vacuoles (for a review, see Swanson and Watts, 1995).

Via: biologists.org
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LeciPlex, invasomes, and liposomes: A skin penetration study - ScienceDirect jpg 500x200

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LeciPlex, invasomes, and liposomes: A skin penetration study - ScienceDirect


Bacillary Angiomatosis Roberto N. Miranda, MD Key Facts Terminology Nodules of small blood vessels resulting from infection by bacterium Bartonella henselae Etiology/Pathogenesis B. henselae and B. quintana are most common agents isolated from BA Domestic cats are major reservoir for B. henselae; transmitted by fleas from cat to cat Clinical Issues Most affected patients are…

Via: sciencedirect.com
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SEM analysis of invasome-mediated invasion. HUVECs were infected with... |  Download Scientific Diagram png 850x1021

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SEM analysis of invasome-mediated invasion. HUVECs were infected with... | Download Scientific Diagram


In contrast, we found that two of the three BID domains of BepF are capable to trigger invasome formation together with BepC, while a mutation of the WxxxE motif of the BID-F1 domain inhibited its ability to contribute to the formation of invasome structures. Next, we show that BepF function during invasome formation can be replaced by the over-expression of constitutive-active Rho GTPases Rac1 or Cdc42. Finally we demonstrate that BID-F1 and BID-F2 domains promote the formation of filopodia ...

Via: researchgate.net
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PLOS ONE: BID-F1 and BID-F2 Domains of Bartonella henselae Effector Protein  BepF Trigger Together with BepC the Formation of Invasome Structures  1290x1111

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PLOS ONE: BID-F1 and BID-F2 Domains of Bartonella henselae Effector Protein BepF Trigger Together with BepC the Formation of Invasome Structures


Abstract. The VirB/D4 type IV secretion system (T4SS) of the bacterial pathogen Bartonella henselae (Bhe) translocates seven effector proteins (BepA-BepG) into human cells that

Via: plos.org
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Accepted Manuscript (unedited) Abstract  968x464

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Accepted Manuscript (unedited) Abstract


Purpose: To determine the effect of particle size and viscosity of suspensions on topical ocular bioavailability of budesonide, a corticosteroid drug. Methods: Budesonide microparticle and nanoparticle (MP and NP) suspensions were prepared with or without homogenization and microfluidization. Using different grades of hydroxyl propyl methyl cellulose, low viscosity NP (NP-LV) and low and high ...

Via: tbzmed.ac.ir
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Nanomaterials | Free Full-Text | Invasome: A Novel Nanocarrier for  Transdermal Drug Delivery png 3297x1613

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Nanomaterials | Free Full-Text | Invasome: A Novel Nanocarrier for Transdermal Drug Delivery


Tip-enhanced Raman scattering for tracking of invasomes in the stratum corneum General subjects Author: Ashtikar, Mukul, Langelüddecke, Lucas, Fahr, Alfred, Deckert, Volker Source: Biochimica et biophysica acta 2017 v.1861 no.11 pp. 2630-2639 ISSN:

Via: mdpi.com
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Smart invasome synthesis, characterizations, pharmaceutical applications,  and pharmacokinetic perspective: a review | Future Journal of  Pharmaceutical Sciences | Full Text png 685x375

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Smart invasome synthesis, characterizations, pharmaceutical applications, and pharmacokinetic perspective: a review | Future Journal of Pharmaceutical Sciences | Full Text


Additional file 1: Table S1. of The invasome of Salmonella Dublin as revealed by whole genome sequencing Manal Mohammed, Simon Hello, & Rene Hendriksen Dataset published 2017 via Figshare

Via: springeropen.com
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A translocated protein of Bartonella henselae interferes with endocytic  uptake of individual bacteria and triggers uptake of large bacterial  aggregates via the invasome - Rhomberg - 2009 - Cellular Microbiology -  Wiley Online Library gif 800x775

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A translocated protein of Bartonella henselae interferes with endocytic uptake of individual bacteria and triggers uptake of large bacterial aggregates via the invasome - Rhomberg - 2009 - Cellular Microbiology - Wiley Online Library


The invention relates to invasomes comprising a lipid mixture comprising one or more lipids, preferably neutral lipids, one or more lysophosphatides and at least one pharmacological agent, preferably an immunomodulator, to the preparation thereof and to the use thereof for the therapy of disorders, preferably of disorders which can be treated by modulation of the immune system.

Via: wiley.com
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PDF) Invasome: A Novel Nanocarrier for Transdermal Drug Delivery png 850x1203

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PDF) Invasome: A Novel Nanocarrier for Transdermal Drug Delivery


Invasome formation and internalization is an actin- and β1-integrin-dependent process. The massive cytoskeletal rearrangements resulting in invasome-mediated uptake of bacterial aggregates are entirely dependent on the VirB type IV secretion system, but the specific effectors involved are unknown. Interestingly , Bartonella also invades erythrocytes, in this case, with an essential role for ...

Via: researchgate.net
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Combined action of the type IV secretion effector proteins BepC and BepF  promotes invasome formation of Bartonella henselae on endothelial and  epithelial cells - Truttmann - 2011 - Cellular Microbiology - Wiley Online  Library gif 475x1212

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Combined action of the type IV secretion effector proteins BepC and BepF promotes invasome formation of Bartonella henselae on endothelial and epithelial cells - Truttmann - 2011 - Cellular Microbiology - Wiley Online Library


The invasome of Salmonella Dublin as revealed by whole genome sequencing. BMC Infect Dis 17: 544. doi: 10.1186/s12879-017-2628-x. OpenUrl CrossRef. 4. ↵ Mohammed M, Cormican M. 2016. Whole genome sequencing provides insights into the genetic determinants of invasiveness in Salmonella Dublin. Epidemiol Infect 144: 2430 - 2439. doi: 10.1017/S0950268816000492. OpenUrl CrossRef. 5. ↵ Cadel ...

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BID-F1 and BID-F2 Domains of Bartonella henselae Effector Protein BepF  Trigger Together with BepC the Formation of Invasome Structures g002 1041x1781

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BID-F1 and BID-F2 Domains of Bartonella henselae Effector Protein BepF Trigger Together with BepC the Formation of Invasome Structures


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Figure 7 from Interaction of Bartonella henselae with endothelial cells  results in bacterial aggregation on the cell surface and the subsequent  engulfment and internalisation of the bacterial aggregate by a unique  structure, png 1442x1472

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Figure 7 from Interaction of Bartonella henselae with endothelial cells results in bacterial aggregation on the cell surface and the subsequent engulfment and internalisation of the bacterial aggregate by a unique structure,


Chlamydia trachomatis is the etiologic agent of the most prevalent sexually transmitted infection (STI) in industrialized nations and the blinding condition, trachoma, in under-developed countries. Th...

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Invasomes: Potential vesicular systems for transdermal delivery of drug  molecules - ScienceDirect jpg 535x347

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Invasomes: Potential vesicular systems for transdermal delivery of drug molecules - ScienceDirect


invasome (by ~ 15 and 4.5 folds respectively) while showed liposome slight insignificant higher accumulation than liposome in SC. Going deeper into epidermis and dermis, vesicular systems and ethanolic solution improved accumulation when compared with buffered solution.

Via: sciencedirect.com